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Invitrogen™ PLD2 Polyclonal Antibody

Beskrivning
Reconstitute at 0.2 mg/mL in sterile PBS.
PLD2 is a peripheral membrane protein belonging to phospholipase D family with a PH domain, two PLD phosphodiesterase domains and a PX (phox homology) domain that plays a regulatory rather than catalytic role. PLD2 catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid and choline. PLD2 may function in regulated secretion, signal-induced cytoskeletal regulation and/or endocytosis, transcriptional regulation, and cell cycle control. It is usually stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and activated by the ADP-ribosylation factor-1 (ARF-1). PLD2 is activated by agonist stimulation of both tyrosine kinase and G protein-coupled receptors and is also known to interact with EGFR and PIP5K1A. PLD2, localized to plasma membrane caveolae, is ubiquitously expressed in most tissues.
Specifikationer
Specifikationer
| Antigen | PLD2 |
| Användningsområden | Immunohistochemistry (Paraffin), Western Blot |
| Klassificering | Polyclonal |
| Koncentration | 0.2 mg/mL |
| Konjugera | Unconjugated |
| Formulering | PBS with trehalose and no preservative |
| Gen | Pld2 |
| Genaccessionsnr. | O14939 |
| Gene Alias | choline phosphatase 2; hPLD2; phosphatidylcholine-hydrolyzing phospholipase D2; phospholipase D gene 2; phospholipase D2; PLD 2; PLD1C; PLD2; Pldc; rPLD2 |
| Gensymboler | Pld2 |
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Produkttitel
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