missing translation for 'onlineSavingsMsg'
Learn More

Invitrogen™ PLK4 Recombinant Human Protein

PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases. Recombinant human PLK4 (1-836) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Brand:  Invitrogen™ PV6394

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15449023

  • 4230.00 SEK / 10µg
Estimated Shipment: 15-04-2024
to see stock.

Please to purchase this item. Need a web account? Register with us today!


Description

Description

PLK4 localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells.The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development.

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance
  • Multiple pack sizes available for convenient use
Specifications

Specifications

Enzyme and Protein Activity Assay, Industrial and Applied Science, Kinase Assay, Kinase Biology, Kinase Proteins and Expression Reagents, Pharma and Biopharma, Protein Assays and Analysis, Protein Biology, Target and Lead Identification and Validation
120.9kDa
Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.
aa 1-836
Recombinant
50mM Tris-HCl pH 7.5, 150mM NaCl, 0.25mM DTT, 10mM glutathione, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol
10μg
SAK, STK18
Human
GST Tag
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers