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STEMCELL Technologies Pluripotin

Produktkod. 17110132
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17110132 1 mg
17120132 10 mg
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Produktkod. 17110132 Leverantör STEMCELL Technologies Leverantörsnummer 72812

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Beskrivning

PI3K and MEK/ERK pathway inhibitor; Inhibits RasGAP and ERK1

  • Pluripotin inhibits both Ras GTPase-activating protein (RasGAP, Kd = 98 nM) and extracellular signal-regulated kinase 1 (ERK1, Kd = 212 nM; Chen et al.) Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK1 blocks differentiation (Chen et al.)
  • Promotes self-renewal and maintains mouse embryonic stem (ES) cells in an undifferentiated, pluripotent state in the absence of feeder cells, serum and leukemia inhibitory factor (LIF) for at least 10 passages (Chen et al.; Xiong et al.)
  • When combined with LIF, improves efficiency of ES cell derivation from refractory mouse strains (Pieters et al.; Yang et al.)

Specifikationer

CAS 839707-37-8
Synonym SC-1
Kvantitet 1 mg
Molekylformel C27H25F3N8O2
Renhet ≥98%
Produkttitel
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