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Podoplanin Rat anti-Human, PE, Clone: NZ-1.3, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-9381-42

Additional Details : Weight : 0.23750kg

Product Code. 15507206

  • 2590.00 SEK / 100 tests


EU Stock 15
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Description

Description

Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.
Specifications

Specifications

Podoplanin
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
Q86YL7
CTA-520D8.1, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
NZ-1.3
PE
PDPN
Liquid
PDPN
IgG2a
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
10630
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