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Pokemon (LRF) Armenian Hamster anti-Human, Clone: 13E9, eBioscience™

Armenian Hamster Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-3309-80

Additional Details : Weight : 0.01000kg

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Product Code. 15237347

  • 916.00 SEK / 25µg

Estimated Shipment
21-07-2021

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Description

Description

Description: This monoclonal antibody reacts with human Leukemia/lymphoma-related factor (LRF). This 65-kDa protein is also known as POKEMON, FBI-1, and Zbtb7a. LRF is a member of the POK family of transcriptional repressors, and is expressed in hematopoietic stem cells, T and B lymphocytes, macrophages, and erythroid cells. This protein is also highly expressed in human non-Hodgkin′s lymphoma tissues and diffuse large B-cell lymphomas, demonstrating its prominent role in oncogenic transformation. Studies have demonstrated that LRF is also involved in B cell lineage commitment and development by opposing Notch signaling. Moreover, LRF is critical for erythroid terminal differentiation in the bone marrow by inhibiting Bim-mediated apoptosis. Finally, LRF interacts with Bcl-6 in germinal center B cells. Applications Reported: This 13E9 antibody has been reported for use in immunoblotting (WB) and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections. Applications Tested: This 13E9 antibody has been tested by western blot analysis of the A20 cell line and by immunohistochemical staining of formalin-fixed paraffin embedded human tonsil tissue. This can be used at 1-10 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.

2 µm post- manufacturing filtered. Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5′-[GA][CA]GACCCCCCCCC-3′.
Specifications

Specifications

Pokemon (LRF)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
O95365
DKFZp547O146, FBI-1, FBI1, LRF, MGC99631, ZBTB7, ZNF857A, pokemon
Armenian Hamster
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
13E9
Unconjugated
ZBTB7A
Liquid
ZBTB7A
IgG
25 μg
4° C
Primary
51341
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SDS
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For Research Use Only.