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Tocris Bioscience™ PP 242
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Produktkod. 18766436
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25 mg
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18766436 25 mg
18707446 5 mg
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Produktkod. 18766436 Leverantör Tocris Bioscience™ Leverantörsnummer 4257/25

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Beskrivning

Dual mTORC1/mTORC2 inhibitor

PP 242 is an ATP-competitive mTORC1/mTORC2 inhibitor (IC50 = 8 nM). Displays selectivity for mTOR over other PI 3K family kinases (IC50 values are 0.102, 0.408, 1.27, 1.96 and 2.2 μM for p110γ, DNA-PK, p110δ, p110α and p110β respectively) and 215 further kinases. Displays modest inhibition of PKCα, JAK2, PKCβI, PKCβII and RET (IC50 values are 0.049, 0.110, 0.185, 0.198 and 0.224 μM respectively). Inhibits both S6K and 4EBP1 phosphorylation; activity causes a decrease in cap-dependent protein translation. Also triggers downregulation of cFLIPS and augments TRAIL-induced apoptosis of cancer cells. PP 242 also inhibits oncogenic K-Ras and PI 3-K induced lipogenesis in breast cancer cells.
TRUSTED_SUSTAINABILITY

Specifikationer

Kemiskt namn eller material 2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol
CAS 1092351-67-1
Analysprocentintervall >98%
Kvantitet 25 mg
Molekylformel C16H16N6O
Formel vikt Observed MW: 308.34
Produkttitel
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