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Presenilin-1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1236.20 SEK - 3313.85 SEK

Specifications

Antigen Presenilin-1
Concentration 0.13 mg/mL
Applications Immunoprecipitation, Western Blot
Conjugate Unconjugated
Format Liquid
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16825694
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Proteintech
16163-1-AP-150UL
150 μL
3313.85 SEK
150µL
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Estimated Shipment: 20-01-2022
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16835694
View Documents Promotion Details
Proteintech
16163-1-AP-20UL
20 μL
1236.20 SEK
20µL
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Estimated Shipment: 20-01-2022
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Description

Description

This antibody is specific to isoform 1 (53 kDa), isoform 2 (52 kDa), isoform 4 (21 kDa), isoform 7 (49 kDa) of this protein.

Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer′s disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer′s disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer′s disease. Multiple isoforms of presenilin1 are known to exist. This antibody has no cross-reactivity to presenilin2.
Specifications

Specifications

Presenilin-1
Immunoprecipitation, Western Blot
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Polyclonal
-20°C
0.13 mg/mL
Unconjugated
Rabbit
Human, Mouse, Rat
IgG
Antigen Affinity Chromatography
Antibody
SDS
Product Certifications