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PROC Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 25382-1-AP-20UL
Additional Details : Weight : 0.00010kg
Description
Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55kDa and the normal concentrations in human plasma is approximately 1-3 ng/ml because of the very fast turnover, the proenzyme concentration is approximately 3 μg/ml. Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulmis, and recurrent venous thrombosis.Specifications
PROC | |
Polyclonal | |
Unconjugated | |
PROC | |
Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, PC, PROC, PROC1, Vitamin K dependent protein C | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
19123, 5624 | |
-20°C | |
Liquid |
Western Blot, Immunohistochemistry (Paraffin) | |
0.34 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
P04070, P33587 | |
Proc | |
PROC Fusion Protein Ag11328 | |
20 μL | |
Primary | |
Mouse, Human | |
Antibody | |
IgG |