Invitrogen™ Protein APC Polyclonal Antibody

Beskrivning

Immunogen sequence: QSKENQVSAK GTWRKIKENE FSPTNSTSQT VSSGATNGAE SKTLIYQMAP AVSKTEDVWV RIEDCPINNP RSGRSPTGNT PPVIDSVSEK ANPNIKDSKD NQAKQNVGNG SVPMRTVGLE NRLNSFIQVD APDQKGTEIK PGQNNPVPVS ETNESSIVER T Positive Samples: HeLa; Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, adherens junction, cytoskeleton, lamellipodium, ruffle membrane.

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.