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Tocris Bioscience™ (R)-CR8
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Produktkod. 18034532
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Kvantitet:
10 mg
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Produktkod. Kvantitet
18034532 10 mg
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Produktkod. 18034532 Leverantör Tocris Bioscience™ Leverantörsnummer 3605/10

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Beskrivning

Cdk inhibitor; potently inhibits cdk1 and cdk2; also inhibits CK1; acts as molecular glue

(R)-CR8 is a cyclin dependent kinase (cdk) inhibitor (reported IC50 values are 0.036 - 0.07, 0.09 - 0.8, 0.13 - 0.68, 0.18 - 1 and >1 μM for cdk2, cdk1, cdk5, cdk9 and cdk7, respectively). Also inhibits casein kinase 1 (CK1; IC50 = 0.6 μM). Acts as molecular glue; forms a complex between CDK12-cyclin K and the CUL4 adapter protein DDB1 resulting in ubiquination and degradation of cyclin K.
TRUSTED_SUSTAINABILITY

Specifikationer

CAS 1786438-30-9
Kvantitet 10 mg
Molekylformel C24H29N7O0.3 HCl
Produkttyp (2R)-2-[[9-(Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol trihydrochloride
Renhet 99%
Molekylvikt (g/mol) M.W. (Observed): 540.92
Inhibitorer (R)-CR8

For Research Use Only

Produkttitel
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