missing translation for 'onlineSavingsMsg'
Läs mer
  1. Home
  2. Products
  3. Proteinanalysreagenser
  4. Bioaktiva små molekyler
  5. Tocris Bioscience™ JTE 607 Dihydrochloride

Tocris Bioscience™ JTE 607 Dihydrochloride
GREENER_CHOICE

Produktkod. 18766658
Change view
Klicka för att se tillgängliga alternativ
Kvantitet:
10 mg
50 mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Produktkod. Kvantitet
18766658 50 mg
18733939 10 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
Denna artikel kan inte returneras. Se returpolicy
Produktkod. 18766658 Leverantör Tocris Bioscience™ Leverantörsnummer 5185/50

Please to purchase this item. Need a web account? Register with us today!

Denna artikel kan inte returneras. Se returpolicy

Beskrivning

Cytokine release inhibitor; anti-inflammatory

JTE 607 dihydrochloride is a pro-drug that is cleaved by carboxylesterase 1 (CES1) to its active metabolite, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3; Kd = 370 nM at human CPSF3). Treatment of A-673 cells with JTE 607 results in inhibition of mRNA cleavage and accumulation of nuclear R-loops. JTE 607 induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model. JTE 607 inhibits cytokine release and inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. In a rat model of lung injury, JTE 607 reduces proinflammatory cytokine-release and attenuates lung permeability.
TRUSTED_SUSTAINABILITY

Specifikationer

Kemiskt namn eller material JTE 607 dihydrochloride
CAS 188791-09-5
Synonym N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
Kvantitet 50 mg
Löslighet Soluble to 100mM in water and to 100mM in DMSO
Molekylformel C25H31Cl2N3O5·2HCl
Formel vikt 597.36
Fysisk form Solid
Produkttyp Bioactive Small Molecule
Renhet >98%

Research Use Only. Not For Human or Veterinary Use

Produkttitel
Välj ett problem

Genom att klicka på Skicka bekräftar du att du kan bli kontaktad av Fisher Scientific angående feedbacken du har lämnat i detta formulär. Vi kommer inte att dela din information för andra ändamål. All kontaktinformation som tillhandahålls ska också underhållas i enlighet med vår Sekretesspolicy.