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  6. 18756228

Tocris Bioscience™ PFI 4

Potent and selective BRPF1 bromodomain inhibitor

Brand:  Tocris Bioscience™ 5576/10

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Product Code. 18756228

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Description

Description

PFI 4 is a potent and selective BRPF1B bromodomain inhibitor (IC50 = 172 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. Disrupts BRPF1 binding to histone H3.3. Cell permeable. Inhibits osteoclastogenesis.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PFI 4
N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide
Soluble to 50mM in DMSO and to 10mM in ethanol
380.44
Bioactive Small Molecule
900305-37-5
10 mg
C21H24N4O3
Solid
>99%
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