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LIMK2 (phospho T505), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Produktkod. 16085567
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Kvantitet:
100 μg
Förpackningsstorlek:
100µg
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16085567 100 μg 100µg
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Produktkod. 16085567 Leverantör Abnova Leverantörsnummer PAB25375.100ug

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Beskrivning

Rabbit polyclonal antibody raised against synthetic phosphopeptide of LIMK2.

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Sequence: R-Y-Tp-V-V

Specifikationer

Antigen LIMK2
Användningsområden Immunohistochemistry (PFA fixed), Western Blot
Klassificering Polyclonal
Konjugera Unconjugated
Beskrivning Rabbit polyclonal antibody raised against synthetic phosphopeptide of LIMK2.
Utspädning Western Blot (1:500-1:1000) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.
Formulering In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Gen LIMK2
Gensymboler LIMK2
Värd art Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues surrounding T505 of human LIMK2.
Reningsmetod Affinity purification
Kvantitet 100 μg
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 3985
Målarter Human, Mouse, Rat
Innehåll och lagring Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

Produkttitel
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