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RAF1 (phospho S259), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Produktkod. 16055457
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Kvantitet:
100 μg
Förpackningsstorlek:
100µg
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16055457 100 μg 100µg
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Produktkod. 16055457 Leverantör Abnova Leverantörsnummer PAB25227.100ug

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Beskrivning

Rabbit polyclonal antibody raised against synthetic phosphopeptide of RAF1.

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq

Sequence: S-T-Sp-T-P

Specifikationer

Antigen RAF1
Användningsområden Immunohistochemistry (PFA fixed), Western Blot
Klassificering Polyclonal
Koncentration 1 mg/mL
Konjugera Unconjugated
Beskrivning Rabbit polyclonal antibody raised against synthetic phosphopeptide of RAF1.
Utspädning Immunohistochemistry (1:50-1:100) Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.
Formulering In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Gen RAF1
Gene Alias CRAF/NS5/Raf-1/c-Raf
Gensymboler RAF1
Värd art Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues surrounding S259 of human RAF1.
Reningsmetod Affinity chromatography
Kvantitet 100 μg
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 5894
Målarter Human, Mouse, Rat
Innehåll och lagring Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

Produkttitel
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