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VAV1 (phospho Y174), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™
Beskrivning
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq
Specifikationer
Specifikationer
| Antigen | VAV1 |
| Användningsområden | Western Blot |
| Klassificering | Polyclonal |
| Konjugera | Unconjugated |
| Beskrivning | Rabbit polyclonal antibody raised against synthetic phosphopeptide of VAV1. |
| Utspädning | Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user. |
| Formulering | In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide) |
| Gen | VAV1 |
| Gene Alias | VAV |
| Gensymboler | VAV1 |
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For Research Use Only
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