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RAD51 Monoclonal Antibody (51RAD01 (3C10)), Invitrogen™
Beskrivning
MA5-14419 targets RAD51 in IHC (P), IP, ICC/IF and WB applications and shows reactivity with Human, mouse, and Rat samples. The MA5-14419 immunogen is recombinant Rad51 protein.
RAD51 plays a critical role in homologous strand exchange, a key step in DNA repair through homologous recobination. It binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. RAD51 catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. It binds to a single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Mutations in the gene can results in breast cancer, mirror movements 2 and fanconi anemia.
Specifikationer
Specifikationer
| Antigen | RAD51 |
| Användningsområden | Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot |
| Klassificering | Monoclonal |
| Klona | 51RAD01 (3C10) |
| Koncentration | 0.2 mg/mL |
| Konjugera | Unconjugated |
| Formulering | PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4 |
| Gen | Rad51 |
| Genaccessionsnr. | Q06609, Q08297 |
| Gene Alias | AV304093; BRCA1/BRCA2-containing complex, subunit 5; BRCC5; DNA repair protein RAD51; DNA repair protein RAD51 homolog 1; DNA repair protein RAD51 homolog A; DNA repair protein rhp51; FANCR; homolog to S.cerevisiae; HRAD51; HsRad51; HsT16930; MGC128559 protein; MRMV2; MUT5; rad51; RAD51 homolog; RAD51 homolog (RecA homolog); RAD51 homolog (RecA homolog, E. coli); RAD51 homolog A; RAD51 recombinase; RAD51 recombinase L homeolog; rad51.1; rad51.L; rad51-1; RAD51A; rad51-a; rad51-b; Reca; RecA family recombinase Rhp51; RecA, E. coli, homolog of; RecA-like protein; recombinase RAD51; recombination protein A; RGD1563603; rhp51; SPAC644.14c; wu:fb38e12; xrad51; XRad51.1; YER095W; zgc:77754 |
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Produkttitel
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