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STEMCELL Technologies Rapamycin

Produktkod. 17130212
Encompass_Preferred
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1 mg
10 mg
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1mg
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17130212 10 mg -
15682517 1 mg 1mg
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Produktkod. 17130212 Leverantör STEMCELL Technologies Leverantörsnummer 73364

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Antibiotic; mTOR pathway inhibitor; Inhibits FKBP-12

  • Rapamycin is a macrolide antibiotic and immunosuppressive compound that inhibits mammalian target of rapamycin (mTOR) signaling
  • It acts through formation of a complex with cytosolic FK-binding protein 12 (FKBP-12), which directly binds to mTOR complex 1 (mTORC1)
  • Its immunosuppressive effects are mediated through inhibition of IL-2 signaling that is critical for T-cell proliferation and activation (Gibbons et al.; Kay et al.) Rapamycin shows antifungal activity against Candida albicans and other fungi (Vézina et al.)
  • Inhibits growth of MDA-MB-468 human breast cancer cells in vitro, and inhibits tumor growth in a mouse xenograft model in vivo (Akcakanat et al.)
  • Induces autophagy in malignant glioma cells (Takeuchi et al.)

Specifikationer

CAS 53123-88-9
Kvantitet 10 mg
Procent renhet ≥95%
Produkttitel
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