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Tocris Bioscience™ RU.521
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Produktkod. 18736205
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50 mg
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Produktkod. Kvantitet
18736205 10 mg
18766005 50 mg
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Produktkod. 18736205 Leverantör Tocris Bioscience™ Leverantörsnummer 7904/10

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Beskrivning

Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)

RU.521 is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor (Kd = 36.2 nM; IC50 values are 0.11 μM and 2.94 μM against m-cGAS and h-cGAS, respectively). RU.521 suppresses dsDNA-activated reporter activity but not 5'ppp-HP20 RNA or murine IFN-β-induced IFN-β1-dependent gene expression. RU.521 reduces constitutive expression of type I interferon in primary macrophages from a mouse model of Aicardi-Gouti?res syndrome. Pretreatment of chimeric antigen receptor (CAR) redirected T cells with RU.521 increases efficiency of virus-free gene editing by improving cell viability and CAR integration in cell line.
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Specifikationer

Kemiskt namn eller material 3-[1-(6,7-Dichloro-1 H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1 H-pyrazol-4-yl]-1(3 H)-isobenzofuranone
CAS 2262452-06-0
Kvantitet 10 mg
Mål Synthase/Synthetase Inhibitors
Molekylformel C19H12Cl2N4O3
Renhet 0.98
Produkttitel
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