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RYBP Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 11365-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16828393

  • 1236.20 SEK / 20µL
Estimated Shipment: 08-12-2021

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Description

Description

RYBP involves component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ′Lys-119′, rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A ′Lys-119′ on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A ′Lys-119′ by recruiting the complex to target sites. Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.
Specifications

Specifications

RYBP
0.3 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q8CCI5, Q8N488
AAP1, APAP 1, Apoptin associating protein 1, DED associated factor, DEDAF, RING1 and YY1 binding protein, RYBP, YEAF1
Rabbit
IgG
20 μL
-20°C
Primary
23429, 312603, 56353
Western Blot, Immunoprecipitation
Unconjugated
RYBP
Liquid
Rybp
RYBP Fusion Protein Ag1908
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Rat, Mouse, Human
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