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SB 218078, Tocris Bioscience™

Catalog Number 18054732
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Quantity:
1 mg
10 mg
This item is not returnable. View return policy
135897-06-2
C24H15N3O3
393.402
OTPNDVKVEAIXTI-UHFFFAOYSA-N
9,10,11,12,-tetrahydro-9,12-epoxy-1h-diindolo 1,2,3-fg:3′,2′,1′-kl pyrrolo 3,4-i 1,6 benzodiazocine-1,3 2h-dione, d00kdf, 5,6,7,8-tetrahydro-13h-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo b,h cycloocta jkl cyclopenta e-as-indacene-13,15 14h-dione, 9,10,11,12-tetrahydro-9,12-epoxy-1h-diindolo 1,2,3-fg:3',2',1'-kl pyrrolo 3,4-i 1,6 benzodiazocine-1,3 2h-dione, 9,12-epoxy-1h-diindolo 1,2,3-fg:3',2',1'-kl pyrrolo 3,4-i 1,6 benzodiazocine-1,3 2h-dione, 9,10,11, 9,12-epoxy-1h-diindolo 1,2,3-fg:3',2',1'-kl pyrrolo 3,4-i 1,6 benzodiazocine-1,3 2h-dione,9,10,11,12-tetrahydro
3387354
C1CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C1O2)C7=C53)C(=O)NC6=O
This item is not returnable. View return policy
135897-06-2
C24H15N3O3
393.402
OTPNDVKVEAIXTI-UHFFFAOYSA-N
9,10,11,12,-tetrahydro-9,12-epoxy-1h-diindolo 1,2,3-fg:3′,2′,1′-kl pyrrolo 3,4-i 1,6 benzodiazocine-1,3 2h-dione, d00kdf, 5,6,7,8-tetrahydro-13h-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo b,h cycloocta jkl cyclopenta e-as-indacene-13,15 14h-dione, 9,10,11,12-tetrahydro-9,12-epoxy-1h-diindolo 1,2,3-fg:3',2',1'-kl pyrrolo 3,4-i 1,6 benzodiazocine-1,3 2h-dione, 9,12-epoxy-1h-diindolo 1,2,3-fg:3',2',1'-kl pyrrolo 3,4-i 1,6 benzodiazocine-1,3 2h-dione, 9,10,11, 9,12-epoxy-1h-diindolo 1,2,3-fg:3',2',1'-kl pyrrolo 3,4-i 1,6 benzodiazocine-1,3 2h-dione,9,10,11,12-tetrahydro
3387354
C1CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C1O2)C7=C53)C(=O)NC6=O

Chk1 inhibitor

Inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G2 cell cycle arrest caused by γ-irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics.
Quantity 1 mg
Formula Weight 393.39
Percent Purity >98%
Chemical Name or Material SB 218078
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