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SC144 hydrochloride, MedChemExpress

Produktkod. 16476836
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16462767 50 mg 50mg
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Produktkod. 16476836 Leverantör Medchem Express Leverantörsnummer HY15614A

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Description

MedChemExpress SC144 hydrochloride is a first-in-class, orally active gp130 (IL6-beta) inhibitor.

SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 hydrochloride shows potent inhibition of gp130 ligand-triggered signaling. SC144 hydrochloride induces apoptosis in human ovarian cancer cells.

Specifications

Kemiskt namn eller material SC144 hydrochloride
CAS 917497-70-2
Färg Gray
Anteckningar om renhetsgrad Research
Molekylformel C16H12ClFN6O
Kvantitet 100 mg
Löslighetsinformation DMSO : 10 mg/mL (27.87 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
LEDER O=C(C1=NC=CN=C1)NNC2=NC3=C(N4C2=CC=C4)C=CC(F)=C3.[H]Cl
Molekylvikt (g/mol) 358.76
Formel vikt 358.76
Procent renhet 98.89%
Kvalitet Research
Fysisk form Powder
För användning med (applikation) Cancer-Kinase/protease
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Research purposes only

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