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PeproTech SCF Polyclonal Antibody, PeproTech®, Invitrogen™

Produktkod. 17885793
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Produktkod. 17885793 Leverantör PeproTech Leverantörsnummer 500P48G50UG

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Beskrivning

Goat Polyclonal Antibody

AA Sequence of recombinant protein: MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA. Preparation: Produced from sera of goats immunized with highly pure Recombinant Human SCF. Anti-Human SCF-specific antibody was purified by affinity chromatography employing an immobilized Human SCF matrix. Sandwich ELISA: To detect Human SCF by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human SCF (500-P48GBt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human SCF. Western Blot: To detect hSCF by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant hSCF is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen SCF
Användningsområden ELISA, Western Blot
Klassificering Polyclonal
Koncentration 0.1-1.0 mg/mL
Konjugera Unconjugated
Formulering PBS with no preservative
Gen KITLG
Genaccessionsnr. P21583
Gene Alias 710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; SLF; Soluble KIT ligand; Steel factor; steel factor/kit ligand; stem cell factor; stem cell factor KL-1; stem cell factor, CSF
Gensymboler KITLG
Värd art Goat
Immunogen E.coli-derived Recombinant Human SCF.
Reningsmetod Antigen affinity chromatography
Kvantitet 50 μg
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 4254
Målarter Human
Innehåll och lagring -20°C
Produkttyp Antibody
Form Lyophilized
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