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Invitrogen™ SCK Polyclonal Antibody
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Produktkod. 15730211 Handla allt Thermo Scientific Produkter
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Kvantitet:
100 μL
Förpackningsstorlek:
100µL
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15730211 100 μL 100µL
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Produktkod. 15730211 Leverantör Invitrogen™ Leverantörsnummer PA552258

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Beskrivning

Rabbit Polyclonal Antibody

Immunogen sequence: EHLYVNTQGL DAPEPEDSPK KDLFDMRPFE DALKLHECSV AAGVTAAPLP LEDQWPSPPT RRAPVAPTEE QLRQEPWYHG RMSRRAAERM LRADGD Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 85%.

Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events. Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain. Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary. In vascular endothelial cells, Sck participates in VEGF-induced signal transduction. Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen SCK
Användningsområden Immunohistochemistry (Paraffin), Western Blot
Klassificering Polyclonal
Koncentration 0.1 mg/mL
Konjugera Unconjugated
Formulering PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gen SHC2
Genaccessionsnr. P98077
Gene Alias 6720466E06; neuronal Shc adaptor homolog; protein Sck; Protein Sli; SCK; SH2 domain protein C2; SHC (Src homology 2 domain containing) transforming protein 2; SHC adaptor protein 2; SHC2; ShcB; SHC-transforming protein 2; SHC-transforming protein B; SLI; src homology 2 domain-containing transforming protein C2; src homology 2 domain-containing-transforming protein C2
Gensymboler SHC2
Värd art Rabbit
Immunogen Recombinant protein corresponding to Human SCK. Recombinant protein control fragment (Product #RP-88628).
Reningsmetod Antigen affinity chromatography
Kvantitet 100 μL
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 25759
Målarter Human
Innehåll och lagring Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Produkttyp Antibody
Form Liquid
Isotyp IgG
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Produkttitel
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