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SCN1A Rabbit anti-Human, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 28079-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16825985

  • 1236.20 SEK / 20µL
Estimated Shipment: 07-12-2021

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Description

Description

Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddels syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
Specifications

Specifications

SCN1A
0.33 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P04774, P35498
FEB3, GEFSP2, HBSCI, NAC1, Nav1.1, SCN1, SCN1A, SMEI
Rabbit
IgG
20 μL
-20°C
Primary
6323, 81574
Western Blot
Unconjugated
SCN1A
Liquid
SCN1A
SCN1A Fusion Protein Ag25942
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Rat
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