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SCN9A/Nav1.7 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 20257-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16839784

  • 1236.20 SEK / 20µL
Estimated Shipment: 05-10-2022
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Description

Description

The antibody is specific to SCN9A.

Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddels syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
Specifications

Specifications

SCN9A/Nav1.7
Polyclonal
Unconjugated
SCN9A
ETHA, hNE Na, Nav1.7, NE NA, NENA, Neuroendocrine sodium channel, Peripheral sodium channel 1, PN1, SCN9A
Rabbit
Antigen Affinity Chromatography
RUO
6335
-20°C
Liquid
Immunohistochemistry (Paraffin), Immunocytochemistry, Immunofluorescence
0.28 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q15858
SCN9A
Peptide
20 μL
Primary
Human
Antibody
IgG
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