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SIAH2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 12651-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16840484

  • 3313.85 SEK / 150µL
Estimated Shipment: 05-10-2022
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Description

Description

SIAH-2 (seven in absentia homolog 2) is an E3 ligase that catalyzes ubiquitination and proteasome-mediated degradation of protein substrates. SIAH-2 encodes a 324 amino acid protein that shares 77% identity with human SIAH-1 and 68% identity with the Drosophila sina (seven in absentia) gene, on which development of the Drosophila R7 photoreceptor is dependent. SIAH-2 targets TRAF2 (which regulates cell responses to stress and cytokines through the regulation of key stress-signaling cascades) for degradation under stress conditions such as hypoxia. It targets HIF-1 alpha prolyl hydroxylase 3 (PHD3) for degradation upon exposure to hypoxic conditions, which coincides with an increase in SIAH-2 transcription. SIAH-2 can decrease TNF-alpha-dependent induction of JNK activity and transcriptional activation of NFkB. SIAH-2 null mice subjected to hypoxia display an impaired respiratory response and reduced levels of hemoglobin.
Specifications

Specifications

SIAH2
Polyclonal
Unconjugated
SIAH2
hSiah2, Seven in absentia homolog 2, Siah 2, SIAH2
Rabbit
Antigen Affinity Chromatography
RUO
140593, 20439, 6478
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
0.27 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O43255, Q06986, Q8R4T2
SIAH2
SIAH2 Fusion Protein Ag3342
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
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