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Siglec-G Mouse anti-Mouse, APC, Clone: SH2.1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-5833-80

Additional Details : Weight : 0.09500kg

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Product Code. 15508146

  • 1258.00 SEK / 25µg


EU Stock 1
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Description

Description

2 μm post-manufacturing filtered. Siglec-G is an inhibitory receptor that is expressed in a B cell-specific manner with B1 B cells expressing the highest levels of siglec-G. When overexpressed, siglec-G inhibits B cell receptor-mediated calcium signaling. Siglec-G-deficient mice show a massive expansion of the B1a cell population as well as higher titers of natural IgM antibodies. Siglec-G-deficient B1a cells show a lower level of spontaneous apoptosis and a prolonged life span, which may result from higher expression levels of the transcription factor NFATc1. Siglec-G-dependent negative regulation exists in B1 cells, which may explain the naturally muted signaling response of B1 cells.
Specifications

Specifications

Siglec-G
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Liquid
Siglecg
IgG1, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
243958
Flow Cytometry
SH2.1
APC
Siglecg
Sialic Acid-Binding Immunoglobulin-Like Lectin-G; SiglecG; Siglec10; Siglec 10
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
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