Siglec-G Mouse anti-Mouse, APC, Clone: SH2.1, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 17-5833-80
Additional Details : Weight : 0.09500kg
Description2 μm post-manufacturing filtered. Siglec-G is an inhibitory receptor that is expressed in a B cell-specific manner with B1 B cells expressing the highest levels of siglec-G. When overexpressed, siglec-G inhibits B cell receptor-mediated calcium signaling. Siglec-G-deficient mice show a massive expansion of the B1a cell population as well as higher titers of natural IgM antibodies. Siglec-G-deficient B1a cells show a lower level of spontaneous apoptosis and a prolonged life span, which may result from higher expression levels of the transcription factor NFATc1. Siglec-G-dependent negative regulation exists in B1 cells, which may explain the naturally muted signaling response of B1 cells.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|4° C, store in dark, DO NOT FREEZE!|
|Sialic Acid-Binding Immunoglobulin-Like Lectin-G; SiglecG; Siglec10; Siglec 10|
For Research Use Only.