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SIGLEC H Monoclonal Antibody (eBio440c), PE-Cyanine7, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 25-0333-82

2213.44 SEK valid until 2024-03-29
Use promo code "21615" to get your promotional price.



Additional Details : Weight : 0.09500kg

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Product Code. 15568386

  • 3320.00 SEK / 100µg
Estimated Shipment: 09-04-2024
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Description

Description

Description: The monoclonal antibody eBio440c recognizes Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction. The eBio440c antibody has been shown to inhibit pDC function (inhbits IFN alpha secretion in response to CpG). It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6. Applications Reported: This eBio440c antibody has been reported for use in flow cytometric analysis. Applications Tested: This eBio440c antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

SIGLEC H Monoclonal antibody specifically detects SIGLEC H in Mouse samples. It is validated for Flow Cytometry.
Specifications

Specifications

SIGLEC H
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
0
Siglech
Affinity chromatography
RUO
233274
4° C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
eBio440c
PE-Cyanine7
Siglech
6430529G09Rik; sialic acid binding Ig-like lectin H; Siglec; Siglech; Siglec-H; SIGLEC-like protein
Rat
100 μg
Primary
Mouse
Antibody
IgG2b κ
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