Thermo Scientific™ Sino Biological™ SPP1 Recombinant Human Protein, His Tag
This recombinant protein is expressed from a DNA sequence encoding the pro form of human SPP1 (NP_001035147.1) (Met 1-Asn 314)fused to a polyhistidine tag at the C-terminus
Brand: Thermo Scientific™ 10352H08H25
Additional Details : Weight : 0.01000kg
DescriptionSecreted Phosphoprotein 1 (SPP1) recombinant human protein is supplied as a lyophilized powder. This protein is suitable for use in analysis of protein structure. In general, recombinant proteins can also be used as an immunogen, as a protein standard, or in cell biology research applications.&line-break;Background: Secreted phosphoprotein 1, is a member of the osteopontin family. It is an extracellular structural protein and therefore an organic component of bone. Secreted phosphoprotein 1 is expressed in bone, although it is also expressed in other tissues. Secreted phosphoprotein 1 acts as a cytokine which is involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10. It is essential in the pathway that leads to type I immunity. Secreted phosphoprotein 1 has been implicated as an important factor in bone remodeling. Specifically, research suggests it plays a role in anchoring osteoclasts to the mineral matrix of bones. The fact that Secreted phosphoprotein 1 interacts with multiple cell surface receptors which are ubiquitously expressed makes it an active player in many physiological and pathological processes including wound healing, bone turnover, tumorigenesis, inflammation and ischemia. Therefore, manipulation of plasma Secreted phosphoprotein 1 levels may be useful in the treatment of autoimmune diseases, cancer metastasis, osteoporosis and some forms of stress.
- N-terminal Sequence Analysis: IIe 17
- Activity: The activity of this protein has not been tested
- Formulation: lyophilized in PBS, pH 7.4, 5% mannitol, 5% trehalose, 0.02% Tween™-80
- Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2mg/mL or lower; aliquot and use as soon as possible
Manufactured by Sino Biological (China).
|Proteins, Expression, Isolation & Analysis; Enzyme & Protein Activity Assays; Protein Assay Controls, Reference Standards & Accessories|
|5 x 5μg|
|BNSP, BSPI, ETA-1, mgC110940, OPN|
|Cell Structure/Organelle Proteins|
|>80% by SDS-PAGE|
|Store at -20°C. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles. Expires one year from date of receipt when stored as instructed.|
|Secreted phosphoprotein 1|
For Research Use Only. Not for use in diagnostic procedures.