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Invitrogen™ SKI Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA578166
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Beskrivning
Positive Control: HCT116, HCT116 nuclear extract Predicted Reactivity: Mouse (90%), Chicken (80%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
Specifikationer
| SKI | |
| Polyclonal | |
| Unconjugated | |
| SKI | |
| 2310012I02Rik; 2610001A11Rik; AA062172; AA589460; BC004088; C-ski; Proto-oncogene c-Ski; RGD1565591; SGS; SKI; Ski oncogene; ski oncoprotein; SKI proto-oncogene; ski sarcoma viral oncogene homolog; ski sarcoma viral oncogene homolog (avian); SKV; Sloan-Kettering viral oncogene homolog; v-ski avian sarcoma viral oncogene homolog | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 6497 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 0.43 mg/mL | |
| PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7 | |
| P12755 | |
| SKI | |
| Recombinant protein encompassing a sequence within the center region of Human SKI. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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