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SOAT1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Thermo Scientific PA561455
Additional Details : Weight : 0.02000kg
Description
Immunogen sequence: MVGEEKMSLR NRLSKSRENP EEDEDQRNPA KESLETPSNG RIDIKQLIAK KIKLTAEAEE LKPF Highest antigen sequence identity to the following orthologs: Mouse - 59%, Rat - 67%.
SOAT1 (sterol O-acyltransferase-1), also designated ACAT1, is a homotetra-meric enzyme that catalyzes the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A (acyl-CoA). The gene encoding human SOAT1 maps to chromosome 1 and is expressed as a protein that localizes to the endoplasmic reticulum (ER) in several tissues, including liver, kidney, adrenal glands and macrophages. SOAT1 is involved in cellular cholesterol homeostasis as well as in foam cell formation and the subsequent progression of atherosclerosis. Several SOAT inhibitors have been developed for the treatment of atherosclerosis. SOAT2 (sterol O-acyltransferase-2), also known as ACAT2 (acyl-CoA:cholesterol acyltransferase-2), participates in lipo-protein assembly, catalyzing cholesterol esterification in mammalian cells. SOAT2 is an integral membrane protein that localizes to the endoplasmic reticulum of human intestinal cells. SOAT2 deficiency contributes to severe mental retardation and hypotonus.Specifications
SOAT1 | |
Polyclonal | |
Unconjugated | |
SOAT1 | |
8430426K15Rik; Acact; ACACT1; Acat; ACAT1; ACAT-1; acyl coenzyme A:cholesterol acyltransferase 1; acyl-coenzyme A:cholesterol acyltransferase 1; adrenocortical lipid depletion; ald; AW550831; cholesterol acyltransferase 1; hid; SOAT; SOAT1; STAT; sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1; sterol O-acyltransferase 1 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
6646 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Immunohistochemistry | |
0.2 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
P35610 | |
SOAT1 | |
Recombinant protein corresponding to Human SOAT1 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only