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Sorbitol Dehydrogenase Mouse anti-Human, Clone: OTI2A10, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Thermo Scientific MA524991

Additional Details : Weight : 0.01000kg

Product Code. 15964594

  • 3635.00 SEK / 100µL


Estimated Shipment date
from Supplier 20-09-2019
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Description

Description

Sorbitol Dehydrogenase, also known as L-iditol 2-dehydrogenase, SORD or SORD1, is a 357 amino acid member of the zinc-containing alcohol dehydrogenase family. Widely expressed with highest expression in kidney and in the lens of the eye, Sorbitol Dehydrogenase enzymatically catalyzes the zinc-dependent interconversion of polyols, such as such as sorbitol and xylitol, to their respective ketoses. These reactions require NAD+ as an oxidizing agent and, together with Aldose Reductase, they comprise the sorbitol pathway that is involved in sugar production. Sorbitol Dehydrogenase deficiency leads to defects in this pathway and a subsequent accumulation of sorbitol within the cell, a condition that may be associated with diabetic complications such as cataracts and microvascular problems.
Specifications

Specifications

Sorbitol Dehydrogenase
Monoclonal
0.7 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q00796
SORD 1, SORD, SORD1, Sorbitol dehydrogenase
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6652
Immunoprecipitation, Western Blot
OTI2A10
Unconjugated
SORD
Liquid
SORD
Full-length protein expressed in 293T cell transfected with human SORD expression vector
Protein A
RUO
Antibody
Monoclonal
Human
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