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Invitrogen™ SP1 Polyclonal Antibody

Beskrivning
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
Specifikationer
Specifikationer
| Antigen | SP1 |
| Användningsområden | Western Blot |
| Klassificering | Polyclonal |
| Koncentration | 0.5 mg/mL |
| Konjugera | Unconjugated |
| Formulering | TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3 |
| Gen | SP1 |
| Genaccessionsnr. | O89090 |
| Gene Alias | 1110003E12Rik; AA450830; AI845540; HGNC:11205; SP1; Sp1 transcription factor; Sp1-1; specificity protein 1; trans-acting transcription factor 1; transcription factor Sp1; TSFP1 |
| Gensymboler | SP1 |
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Produkttitel
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