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SP110 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 11502-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16878623

  • 1236.20 SEK / 20µL
Estimated Shipment: 08-12-2021

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Description

Description

Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.
Specifications

Specifications

SP110
0.17 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q8BVK9, Q9HB58
IFI41, IFI75, IPR1, SP110, SP110 nuclear body protein, Speckled 110 kDa, VODI
Rabbit
IgG
20 μL
-20°C
Primary
109032, 3431
Immunoprecipitation, Western Blot
Unconjugated
SP110
Liquid
SP110
SP110 Fusion Protein Ag2042
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
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