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  5. Tocris Bioscience™ SSYA10-001

Tocris Bioscience™ SSYA10-001
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Produktkod. 18738066
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18738066 50 mg
18716586 10 mg
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Product Code. 18738066 Supplier Tocris Bioscience™ Supplier No. 7554/50

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Description

Potent coronavirus helicase inhibitor; also inhibits human papillomavirus E6

SSYA10-001 is a potent coronavirus helicase inhibitor (IC50 values are 0.046 μM and >3 μM for unwinding and ATPase, respectively). Inhibits SARS-CoV-2 Nsp13 helicase (IC50 = 3.5 μM), blocks dsDNA and dsRNA unwinding activities of Nsp13 (IC50 values are 5.3 μM and 5.7 μM respectively). In a SARS-CoV replicon assay SSYA10-001 inhibits (+) sense but not (-) sense RNA synthesis (EC50 = 8.95 μM). Also inhibits human papillomavirus E6 (IC50 = 10 μM)
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Specifications

Kemiskt namn eller material 2,4-Dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3 H-1,2,4-triazole-3-thione
CAS 675104-49-1
Kvantitet 50 mg
Mål Antiviral Compounds
Molekylformel C12H12N4O2S2
Renhet 0.98
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