Epredia™ Steroidogenic Factor-1 (SF-1), Clone N1665, Mouse Monoclonal Antibody

Description

Streroidogenic Factor 1 (SF-1) is an orphan nuclear receptor belonging to the NR5A subgroup involved in gonadal and adrenal development. It may regulate genes by forming homodimers, heterdimers or as a monomer. A study by Y Tian et al suggests a significant correlation between the expression levels of SF-1 and StAR and stage of endometriosis in ectopic endometria; with higher levels observed in early stage. SF-1 is valuable in differential diagnosis of various types of ovarian tumors as well as in detecting endometrioid alterations². SF-1 is a highly sensitive and specific differential diagnosis marker of ovarian sertoli cell tumors⁴. SF-1 expression is of stage- independent prognostic value in adrenocortical tumors and in determining adenocortical origin of an adrenal mass³. SF-1 plays a key role in the development of steroidogenic tissues, the regulatory of steroid biosynthesis and the pathogenesis of adrenocortical carcinoma⁵.

Host Species: Mouse
Clone: N1665
Isotype: IgG1
Species Reactivity: Human. Others not tested
Epitope: Not determined
Immunogen: E.coli expressed recombinant SF-1 (220-461 aa)
Molecular Weight: ∼55kDa
Positive Control: Adrenal gland and spleen
Cellular Localization: Nuclear with occasional cytoplasmic
Recommended for: Immunohistochemistry