Invitrogen™ STMN4 Polyclonal Antibody

Beskrivning

Immunogen sequence: MTLAAYKEKM KELPLVSLFC SCFLADPLNK SSYKYEGWCG RQCRRKDESQ RKDSADWRER RAQADTVDLN WCVISDMEVI ELNKCTSGQS FEVILKPPSF DGVPEFNASL PRRRDPSLEE IQKKLEAAEE RRKYQEAELL KHLAEKREHE REVIQKAIEE NNNFIKMAKE KLAQKMESNK ENREAHLAAM LERLQEKDKH AEEVRKNKEL KEEASR; Positive Samples: Mouse spinal cord, Rat spinal cord; Cellular Location: Cell projection, Golgi apparatus, axon, growth cone.

RB3 (Stathmin-4), encoded by STMN4 gene, is a neuron-specific homologue of the SCG10/stathmin family proteins, possessing a unique N-terminal membrane-associated domain and the stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and/or tubulin sequestering. Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and RB3 may be a critical target for neurodegenerative diseases.