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STEMCELL Technologies SU5416​

Produktkod. 17160222
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17160222 10 mg
17170222 50 mg
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Produktkod. 17160222 Leverantör STEMCELL Technologies Leverantörsnummer 73442

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Beskrivning

Tyrosine kinase inhibitor; Inhibits KDR, PDGFR, KIT, RET, FLT-3, ABL, and ALK

  • SU5416 is a tyrosine kinase inhibitor best known as an ATP-competitive inhibitor of the kinase insert domain (KDR/VEGFR2/FLK1)
  • In addition to inhibiting KDR (IC50 = 1 μM), SU5416 also inhibits PDGFR (IC50 = 20 μM), KIT (IC50 = 30 nM), RET (IC50 = 170 nM), FLT-3 (IC50 = 160 nM), ABL (IC50 = 11 μM), and ALK (IC50 = 1.2 μM)
  • SU5416 does not inhibit EGFR or FGFR tyrosine kinases (IC50 > 100 μM; Fong et al.; Litz; Mologni et al.)
  • Prevents angiogenesis, thereby inhibiting tumor growth, catalysis and vascularization for a variety of cancers (Litz; Fong et al.)
  • Inhibits RET-mediated transformation of NIH-3T3 mouse fibroblasts and Ba/F3 mouse pro-B cells (Mologni et al.)
  • Causes pulmonary hypertension in SuHx rat model of pulmonary arterial hypertension, when combined with hypoxia (de Raaf et al.; Mizuno et al.)
  • Inhibits TGFβ1 activation and delays wound healing in rats (Haroon et al.)

Specifikationer

CAS 204005-46-9
Synonym NSC 696819; Semaxinib; Sugen 5416; VEGFR 2 Kinase Inhibitor
Kvantitet 10 mg
Molekylformel C15H14N2O
Renhet ≥98%
Produkttitel
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