missing translation for 'onlineSavingsMsg'
Läs mer
Läs mer
Invitrogen™ SUMO1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA511372
Denna artikel kan inte returneras.
Se returpolicy
Beskrivning
SUMO1 Polyclonal Antibody for Western Blot
SUMO1 is an ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment, via an isopeptide bond, to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO1 is involved, for instance, in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. SUMO1 may also regulate a network of genes involved in palate development. Mutations in the gene can result in non-syndromic orofacial cleft 10.
Specifikationer
| SUMO1 | |
| Polyclonal | |
| Unconjugated | |
| SUMO1 | |
| CG4494-PA; DAP1; GAP modifying protein 1; GAP-modifying protein 1; GMP1; LD07775p; OFC10; OK/SW-cl.43; OTTHUMP00000202403; OTTHUMP00000202404; OTTHUMP00000202405; OTTHUMP00000202406; OTTHUMP00000202409; OTTHUMP00000202410; PIC1; SENP2; sentrin; Sentrin-1; small ubiquitin-like modifier 1; small ubiquitin-related modifier 1; small ubiquitin-related modifier-1; SMT3; SMT3 homolog 3; SMT3 suppressor of mif two 3 homolog 1; SMT3 suppressor of mif two 3 homolog 1 (yeast); Smt3C; Smt3h3; SMTP3; Sumo1; SUMO-1; SUMO-1 related peptidase; Ubiquitin-homology domain protein PIC1; ubiquitin-like 1; ubiquitin-like 1 (sentrin); ubiquitin-like protein SMT3C; Ubiquitin-like protein UBL1; UBL1 | |
| Rabbit | |
| Ammonium sulfate precipitation, Size-exclusion - Dialysis | |
| RUO | |
| 7341 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 2 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.4 | |
| P63165 | |
| SUMO1 | |
| KLH conjugated synthetic peptide between 37-66 amino acids of Drosophila SUMO. | |
| 400 μL | |
| Primary | |
| Drosophila, Human | |
| Antibody | |
| IgG |
Korrigering av produktinnehåll
Din input är viktig för oss. Fyll i det här formuläret för att ge feedback relaterad till innehållet på denna produkt.
Produkttitel
Hittar du en möjlighet till förbättring?Dela en innehållskorrigering