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Survivin Ab-1, Mouse Monoclonal Antibody, Epredia™
Provide accurate, reproducible results with the Epredia™ Survivin Ab-1, Mouse Monoclonal Antibody.
Brand: Epredia MS-1201-P1
Additional Details : Weight : 1.00000kg
Description
Research Areas: Apoptosis; Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.Host Species: Mouse
Clone: 8E2
Isotype: IgG1/κ
Species Reactivity: Human and Rat. Others not known.
Epitope: aa 1-99
Immunogen: Full-length recombinant human survivin protein
Molecular Weight: 16.5kDa
Positive Control: HeLa cells
Cellular Localization: Cytoplasmic and nuclear
Recommended for:
- Immunohistochemistry (Not suitable)
- Western Blotting (Not suitable)
- Immunofluorescence
Note:
USA: RUO; Int'l: RUO
Specifications
| Survivin Ab-1 | |
| Monoclonal | |
| 200μg/mL | |
| Mouse | |
| 500 μL | |
| Apoptosis | |
| Human, Rat | |
| IgG2a κ |
| Immunofluorescence | |
| 8E2 | |
| Unconjugated | |
| Full length recombinant human survivin protein | |
| RUO | |
| Primary | |
| Concentrated |