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Survivin Ab-1, Mouse Monoclonal Antibody, Epredia™

Provide accurate, reproducible results with the Epredia™ Survivin Ab-1, Mouse Monoclonal Antibody.

1183.20 SEK - 5778.30 SEK

Specifications

Antigen Survivin Ab-1
Clone 8E2
Applications Immunofluorescence
Classification Monoclonal
Conjugate Unconjugated
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Products 5
Product Code Brand Concentration Quantity Price Quantity & Availability  
Product Code Brand Concentration Quantity Price Quantity & Availability  
12649256
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Epredia
MS-1201-P1
200μg/mL 500 μL
4845.00 SEK
500µL
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12639256
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Epredia
MS-1201-P0
200μg/mL 100 μL This item is currently unavailable or has been discontinued.
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12629256
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Epredia
MS-1201-P
200μg/mL 1 mL This item is currently unavailable or has been discontinued.
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12659256
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Epredia
MS-1201-P1ABX
1mg/mL 100 μL This item is currently unavailable or has been discontinued.
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Epredia
MS-1201-PABX
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Description

Description

Research Areas: Apoptosis; Survivin, a new inhibitor of apoptosis (IAP) protein, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It indicates that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.

Host Species: Mouse

Clone: 8E2

Isotype: IgG1/κ

Species Reactivity: Human and Rat. Others not known.

Epitope: aa 1-99

Immunogen: Full-length recombinant human survivin protein

Molecular Weight: 16.5kDa

Positive Control: HeLa cells

Cellular Localization: Cytoplasmic and nuclear

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Western Blotting (Not suitable)
  • Immunofluorescence

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

Survivin Ab-1
Immunofluorescence
Unconjugated
Mouse
Apoptosis
Full length recombinant human survivin protein
Primary
8E2
Monoclonal
Concentrated
RUO
Human, Rat
IgG2a κ
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