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Survivin Monoclonal Antibody (STLALYV), Alexa Fluor™ 488, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

2120.00 SEK - 4650.00 SEK

Specifications

Antigen Survivin
Clone STLALYV
Classification Monoclonal
Conjugate Alexa Fluor 488
Form Liquid
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15560267
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Affymetrix eBioscience
53-9176-82
100 μg
4650.00 SEK
100µg
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Estimated Shipment: 07-05-2024
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15550267
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Affymetrix eBioscience
53-9176-80
25 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: This STLALYV monoclonal antibody recognizes human survivin (also known as Birc5). Survivin is a member of the inhibitor of apoptosis (IAP) family that also includes XIAP, c-IAP1, c-IAP2, and NAIP. Survivin functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Survivin also plays a critical role in mitosis and cytokinesis where it is expressed only during G2/M and localizes to the mitotic spindle and is found at the cleavage furrow/midplate. Thus, survivin is highly expressed in tumors and in fetal tissue, but is absent in terminally-differentiated cells and non-proliferating cells. Deletion of survivin in developing thymocytes as well as in mature T cells showed that survivin is critical for cell division in lymphoid cells but not for inhibition of survival; the same is true for B lymphocytes. Applications Reported: This STLALYV antibody has been reported for use in microscopy, and immunocytochemistry. Applications Tested: This STLALYV antibody has been tested by immunocytochemistry of fixed and permeabilized cells and can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.

Survivin Monoclonal antibody specifically detects Survivin in Human samples. It is validated for Immunocytochemistry, Immunohistochemistry.
Specifications

Specifications

Survivin
Monoclonal
Liquid
RUO
O15392
IgG2b κ
Affinity chromatography
STLALYV
Alexa Fluor 488
Mouse
Human
332
Primary
Antibody
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