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Survivin Monoclonal Antibody (STLALYV), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 53-9176-82
Additional Details : Weight : 0.09500kg
Description
Description: This STLALYV monoclonal antibody recognizes human survivin (also known as Birc5). Survivin is a member of the inhibitor of apoptosis (IAP) family that also includes XIAP, c-IAP1, c-IAP2, and NAIP. Survivin functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Survivin also plays a critical role in mitosis and cytokinesis where it is expressed only during G2/M and localizes to the mitotic spindle and is found at the cleavage furrow/midplate. Thus, survivin is highly expressed in tumors and in fetal tissue, but is absent in terminally-differentiated cells and non-proliferating cells. Deletion of survivin in developing thymocytes as well as in mature T cells showed that survivin is critical for cell division in lymphoid cells but not for inhibition of survival; the same is true for B lymphocytes. Applications Reported: This STLALYV antibody has been reported for use in microscopy, and immunocytochemistry. Applications Tested: This STLALYV antibody has been tested by immunocytochemistry of fixed and permeabilized cells and can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.
Survivin Monoclonal antibody specifically detects Survivin in Human samples. It is validated for Immunocytochemistry, Immunohistochemistry.Specifications
| Survivin | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| O15392 | |
| Birc5 | |
| Affinity chromatography | |
| RUO | |
| 332 | |
| 4° C, store in dark, DO NOT FREEZE! | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry | |
| STLALYV | |
| Alexa Fluor 488 | |
| Birc5 | |
| AAC-11; AP14; Api4; apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat containing 5; baculoviral IAP repeat-containing 5; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; BIRC 5; BIRC5; EPR 1; EPR-1; Iap4; inhibitor of apoptosis; survivin; survivin variant 3 alpha; survivin40; SVV; TIAP | |
| Mouse | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2b κ |
For Research Use Only.