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Syk Mouse anti-Human, Clone: 4D10.1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-6696-82

Additional Details : Weight : 0.01000kg

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Product Code. 15227937

  • 2420.00 SEK / 100µg


Estimated Shipment
07-12-2020
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Description

Description

Syk is a cytoplasmic protein tyrosine kinase that translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
Specifications

Specifications

Syk
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P43405
Protein tyrosine kinase p72Syk
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Western Blot
4D10.1
Unconjugated
SYK
Liquid
SYK
IgG2a, kappa
100 μg
4° C
Primary
6850
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SDS
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For Research Use Only.