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Syk Mouse anti-Human, Clone: 4D10.1, eBioscience™

Mouse Monoclonal Antibody

988.00 SEK - 2420.00 SEK

Specifications

Antigen Syk
Clone 4D10.1
Target Species Human
Conjugate Unconjugated
Isotype IgG2a, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15217937
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Affymetrix eBioscience
14-6696-80
25 μg
988.00 SEK
25µg
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Estimated Shipment
07-01-2021
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15227937
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Affymetrix eBioscience
14-6696-82
100 μg
2420.00 SEK
100µg
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Estimated Shipment
07-01-2021
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Description

Description

Syk is a cytoplasmic protein tyrosine kinase that translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
Specifications

Specifications

Syk
Human
IgG2a, kappa
Monoclonal
Liquid
Antibody
4° C
4D10.1
Unconjugated
Flow Cytometry, Western Blot
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.