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Invitrogen™ Human Syk, GST Tag Recombinant Protein

Produktkod. p-7180610
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Kvantitet:
1 mg
10 μg
Förpackningsstorlek:
10µg
1mg
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For Research Use Only. All usage must comply with product instructions.

Produktkod. 11563587

Brand: Invitrogen™ PV3857

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Denna artikel kan inte returneras. Se returpolicy

For Research Use Only. All usage must comply with product instructions.

Beskrivning

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length, Recombinant, Cytoplasmic.

Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
TRUSTED_SUSTAINABILITY

Specifikationer

Tillträdesnummer P43405
Koncentration See Label
För användning med (applikation) Kinase Assay
Formulering 50mM tris HCl with 0.5mM EDTA, 150mM NaCl, 0.02% Triton X-100, 50% glycerol, 2mM DTT and no preservative; pH 7.5
Gen-ID (Entrez) 6850
Molekylvikt (g/mol) 100.1 kDa
Namn Human Syk, GST Tag
pH-intervall 7.5
Reningsmetod Purified
Kvantitet 10 μg
Förvaringskrav -80°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Gene Alias DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK
Vanligt namn Syk
Gensymbol Syk
KinaseFamily SYK Kinase Family
Produkttyp Protein
Konjugera Unconjugated
Art Human
Rekombinant Recombinant
Protein Tag GST-tag
Sekvens Full length
Innehåll och lagring -80°C, Avoid Freeze/Thaw Cycles
Analysinträde Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity, Biochemical binding/kinetic
Kinase Group Tyrosine Kinases
Frakt skick Dry Ice
Systemkompatibilitet LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™, Omnia™ Bulk Substrate
Taggposition N-Terminal
Målinträde SYK
Target Gene spleen tyrosine kinase
Uttryckssystem Baculovirus
Proteinfamilj Kinases & Inhibitors
Proteinform Full Length, Recombinant, Cytoplasmic
Form Liquid
Protein subtyp Cytoplasmic Tyrosine Kinases
Forskningskategori Oncology, Signal Transduction
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