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T-bet Mouse anti-Human, Mouse, Rhesus Monkey, Clone: eBio4B10 (4B10), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5825-82

Additional Details : Weight : 0.01000kg

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Product Code. 15227497

  • 2345.00 SEK / 100µg


In stock, ready to ship: 2
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Description

Description

T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
Specifications

Specifications

T-bet
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q9JKD8, Q9UL17
T-PET, T-bet, TBET, TBLYM, T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; transcription factor TBLYM
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human, Mouse, Rhesus Monkey
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
eBio4B10 (4B10)
Unconjugated
TBX21
Liquid
Tbx21
IgG1, kappa
100 μg
4° C
Primary
30009, 57765, 694044
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