T-bet, PE, clone: eBio4B10 (4B10), eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 12-5825-82
Additional Details : Weight : 0.25000kg
DescriptionIt is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. For intracellular staining with the eBio4B10 monoclonal antibody, it is recommended to use the eBioscience Foxp3/Transcription Factor Staining Buffer Set (cat. 00-5523) and protocol. Please refer to Best Protocols: Protocol B: One step protocol for intracellular (nuclear) proteins). Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|T-PET, T-bet, TBET, TBLYM, T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; transcription factor TBLYM|
|Human, Mouse, Rhesus Monkey|
|eBio4B10 (4B10), 4-B10)|
|4° C, store in dark, DO NOT FREEZE!|
|30009, 57765, 694044|
For Research Use Only.