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Takinib, MedChemExpress

Produktkod. 16496577
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16496577 5 mg
16474886 100 mg
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16433858 10 mg
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Produktkod. 16496577 Leverantör Medchem Express Leverantörsnummer HY103490

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Beskrivning

MedChemExpress Takinib (EDHS-206) is an orally active and selective TAK1 inhibitor (IC50=9.5 nM), more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively.

Takinib is an inhibitor of autophosphorylated TAK1 that non-competitively binds within the ATP binding pocket. Takinib induces apoptosis following TNFα stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Takinib is also a P. falciparum protein kinase 9 (PfPK9) inhibitor (KD(app) of 0.46 μM).

Especificaciones

Kemiskt namn eller material Takinib
Fysisk form Solid
CAS 1111556-37-6
Färg White
Kvantitet 5 mg
Anteckningar om renhetsgrad Research
Molekylformel C18H18N4O2
För användning med (applikation) Cancer-Kinase/protease
Synonym EDHS-206
Löslighetsinformation DMSO : 50 mg/mL (155.11 mM; Need ultrasonic)
LEDER CCCN1C2=CC=CC=C2N=C1NC(C3=CC(C(N)=O)=CC=C3)=O
Molekylvikt (g/mol) 322.36
Formel vikt 322.36
Procent renhet 99.15%
Kvalitet Research
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Research purposes only

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