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Tocris Bioscience™ TASP 0433864, Tocris Bioscience™
Selective mGlu2 receptor positive allosteric modulator
Brand: Tocris Bioscience™ 5362/50
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Beskrivning
TASP 0433864 is a selective mGlu2 receptor positive allosteric modulator (EC50 values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Potentiates inhibitory effect of DCG IV (Cat. No. 0975) on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.Specifikationer
| (2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide | |
| mGlu2 receptor positive allosteric modulator | |
| Soluble to 100mM in DMSO and to 20mM in ethanol | |
| White |
| 1431980-60-7 | |
| 50 mg | |
| Solid | |
| Bioactive Small Molecule |
Produkttitel
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